The effect of the cryoprotectants,dimethylsulfoxide and glycerol on water transport in the human red blood cell |
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Authors: | William C. Small J.H. Goldstein |
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Affiliation: | Department of Chemistry, Emory University, Atlanta, GA 30322 U.S.A. |
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Abstract: | The response of human red blood cells to the cryoprotective agents, DMSO and glycerol, has been investigated using a pulsed NMR method. The experimentally determined parameters are: (1) the intracellular transverse relaxation time, T2a; (2) the mean residence time of intracellular water, τa, which is effectively a reciprocal measure of the rate of water transport across the red blood cell membrane; and (3) the activation energy for this process. The quantitative data indicate that the observed effects are colligative rather than species-specific in origin. |
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Keywords: | Water transport Dimethylsulfoxide Glycerol NMR (Human red blood cell) DMSO dimethylsulfoxide |
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