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Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones |
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| Authors: | Renslo Adam R Gao Hongwu Jaishankar Priyadarshini Venkatachalam Revathy Gómez Marcela Blais Johanne Huband Michael Vara Prasad J V N Gordeev Mikhail F |
| Institution: | Pfizer Global Research and Development, 34790 Ardentech Ct., Fremont, CA 94555, USA. |
| Abstract: | A new class of oxazolidinone antibacterials incorporating oxygen-, nitrogen-, or sulfur-containing heterobicyclic C-rings is described. The in vitro potency and in vivo efficacy of these conformationally constrained oxazolidinone analogs are discussed. |
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