Antibacterial effect of substituted 4-quinazolylhydrazines and their arylhydrazones determined by a modified microdilution method |
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Authors: | S Jantová D Hudecová ? Stankovský K ?pirková L Ru?eková |
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Institution: | (1) Department of Microbiology, Biochemistry and Biology, Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava, Slovakia;(2) Department of Organic Chemistry, Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava, Slovakia |
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Abstract: | Eight 4-quinazolylhydrazines and eleven their arylhydrazones have been tested for antibacterial effects and for structure-activity
relationships by a modifed microdilution method. The derivative 6-chloro-2-morpholino-4-quinazolyl-5′-nitro-2′-furylhydrazone
had the highest antibacterial effect, the MIC values being 100 mg/L forE. fœcalis, 250 mg/L forS. aureus, 200 mg/L forP. aeruginosa and 350 mg/L forE. coli. The most effective derivatives were those with the benzene ring substituted with chlorine or methyl group in position 6
or 8 and with pyrimidine ring substituted with a secondary amine in position 2. The modified microdilution method did not
give rise to any statistically significant deviations in the MIC values for ampicillin in comparison with reported reference
collection values.
Dedicated to Professor Vladimír Betina, DSc. on the occasion of his 65th birthday |
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