Human milk glycoproteins inhibit the adherence of Salmonella typhimurium to HeLa cells |
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Authors: | Bessler Heidi Christina de Oliveira Inaiara Rosa Giugliano Loreny Gimenes |
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Institution: | Laboratório de Microbiologia, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Brazil. |
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Abstract: | The ability of human milk, as well as its protein fractions, to inhibit the adhesion and invasion of Salmonella typhimurium to HeLa cells was investigated. The results revealed that milk secretory immunoglobulin A (sIgA) inhibited neither the adherence nor the bacterial invasion; however, free secretory component and lactoferrin inhibited the bacterial adhesion and interacted with several bacterial proteins. Our data indicated that glycoproteins such as free secretory component and lactoferrin could act as protective compounds against infant enteric diseases, possibly binding to bacterial surface and blocking adhesion, the primordial step of S. typhimurium infection. |
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Keywords: | diarrhea human milk glycoproteins salmonella typhimurium |
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