Notch signalling in the regulation of peripheral T-cell function |
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Authors: | Mckenzie Grahame J Young Lesley L Briend Emmanuel Lamb Jonathan R Dallman Margaret J Champion Brian R |
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Institution: | Lorantis Ltd, 307 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK. grahame.mckenzie@lorantis.com |
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Abstract: | The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor their environment for antigens and respond accordingly by entering one of several potential differentiation pathways. Recent studies have identified a role for the Notch pathway in regulating the responses of T-cells in the periphery. In this review, we discuss these findings in the context of the Notch signalling pathway's role as an orchestrator of cellular differentiation, and propose a central role for Notch as a regulator of immune system function. |
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