| 工业生物催化技术 |
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| 引用本文： | 林章凛,曹竹安,邢新会,刘铮. 工业生物催化技术[J]. 生物加工过程, 2003, 1(1): 12-16 |
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| 作者姓名： | 林章凛 曹竹安 邢新会 刘铮 |
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| 作者单位： | 清华大学 化工系生物化学工程研究所，北京 100084 |
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| 基金项目： | 清华大学“百人计划”基金 |
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| 摘 要： | 以蛋白质酶的工程应用为核心的工业生物催化技术，被认为是生物技术继生物医药和转基因植物之后的第三次浪潮。它的发展与应用将对人类的工业化学过程带来根本的变革。工业生物催化的兴起与以下的两个关键技术因素有密切的关系：(1)蛋白质定向进化技术的出现，(2)基因组学和蛋白质组学的发展。探讨了工业生物催化技术的现状和发展趋势，并对我国如何发展该领域的基础和应用研究提出一些见解。
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| 关 键 词： | 蛋白质酶 工业生物催化 生物转化 定向进化 基因组学 蛋白质组学 |
| 文章编号： | 1672-3678(2003)01-0012-05 |
| 修稿时间： | 2003-03-24 |
Industrial biocatalysis |
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| LIN Zhang-lin,CAO Zhu-an,XING Xin-hui,LIU Zheng. Industrial biocatalysis[J]. Chinese Journal of Bioprocess Engineering, 2003, 1(1): 12-16 |
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| Authors: | LIN Zhang-lin CAO Zhu-an XING Xin-hui LIU Zheng |
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| Abstract: | Biocatalysis, the use of enzymes in industrial processes, is considered the third wave of biotechnology (after biomedicine and transgenic plants) . It has the potential to revolutionize the traditional chemistry -related industries. The rapid advance in biocatalysis since late 1990 s has been driven by two-critical factors:(1) new tools for enzyme engineering such as directed evolution, which make it possible to tailor enzymes for industrial uses; and (2) the genomics and proteomics research, which has provide a huge repertoire of enzymes as well as new biosynthetic routes. Current status and development trends in biocatalysis are reviewed in this report, along with several strategic recommendations for this important area of R&D in China. |
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| Keywords: | biocatalysis enzyme engineering directed evolution genomics proteomics |
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