Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides |
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Authors: | Wimmer Norbert Marano Robert J Kearns Philip S Rakoczy Elizabeth P Toth Istvan |
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Institution: | School of Pharmacy, The University of Queensland, Steele Building, St. Lucia, Qld 4072, Australia. |
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Abstract: | Synthesis of novel polycationic lipophilic peptide core(s) was accomplished and these agents successfully transfected human retinal pigment epithelium cells with ODN1 upon complexation with the oligonucleotide. The level of transfection was indirectly measured by the decreased production of the protein hVEGF (human vascular endothelial growth factor) in comparison to the transfection agent cytofectin GSV. |
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