Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children |
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Authors: | Email author" target="_blank">Kimiko?Yamakawa-KobayashiEmail author Hisako?Yanagi Kazue?Endo Tadao?Arinami Hideo?Hamaguchi |
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Institution: | (1) Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305-8575 Tsukuba , Japan;(2) Institute of Community Medicine, University of Tsukuba, 305-8575 Tsukuba , Japan;(3) School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, 422-8526 Shizuoka , Japan |
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Abstract: | Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels. |
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