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Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase. |
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| Authors: | M L Greenlee J B Laub J M Balkovec M L Hammond G G Hammond D L Pompliano J H Epstein-Toney |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratorie, Rahway, NJ 07065, USA. |
| Abstract: | Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step. |
| Keywords: | |