Synthesis and hybridization property of an oligonucleotide containing a 3-thioformacetal linked pentathymidylate |
| |
Authors: | Zhang J Shaw J T Matteucci M D |
| |
Institution: | Gilead Sciences, Inc., Foster City CA 94404, USA. |
| |
Abstract: | A pentathymidylate fully substituted with 3'-thioformacetal intemucleotidic linkages was synthesized and subsequently incorporated into an oligonucleotide (ON) 15mer. Tm analysis was performed on the resulting ON hybridized with its complementary RNA. This duplex demonstrated slightly improved binding affinity relative to the control phosphate diester ON/RNA hybrid. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|