Isolation and characterization of carboxymycobactins as the second extracellular siderophores in Mycobacterium smegmatis |
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Authors: | Stephen J. Lane Peter S. Marshall Richard J. Upton Colin Ratledge |
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Affiliation: | (1) Physical Sciences Unit, Glaxo Research and Development Ltd., The Medicines Research Centre Stevenage, Hertfordshire, UK;(2) Department of Biological Science University of Hull, UK |
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Abstract: | The structure of a chloroform-extractable siderophore from the supernatant of a nonpathogenic mycobacteria, Mycobacterium smegmatis, has been determined and it closely resembles the structure of mycobactin, the intracellular siderophore found in all mycobacteria. The difference in structures is that the extracellular siderophore has a family of short carboxylic chains attached to the mycobactin nucleus instead of a long alkyl chain and hence the name 'carboxymycobactin' is proposed to distinguish it from mycobactin itself as well as from the major siderophore that is produced - exochelin MS. © Rapid Science 1998. |
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Keywords: | carboxymycobactin exochelin iron Mycobacterium smegmatis mycobactin |
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