DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding. |
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| Authors: | C Welter S Dooley K D Zang N Blin |
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| Affiliation: | Institute of Human Genetics, Medical School, University of Saar, FRG. |
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| Abstract: | DNA bending has been suggested to play a role in the regulation of gene expression, initiation of DNA-replication, site specific recombination, and DNA packaging. In the human mitochondrial DNA we have found a DNA curvature structure within the 3'-region of ther URF2 sequence in front of the L-strand origin of replication. This structure interacts specifically with a protein factor isolated from mitochondria. Based on the localization of this DNA curvature structure and the known function of such structures the data suggest a model in which this DNA signal sequence and its specific protein binding is involved in the regulatory initiation event of L-strand replication. |
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