| 内质网应激与心血管疾病研究概述 |
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| 作者姓名： | He YY He KL Liu CL |
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| 作者单位： | 中国人民解放军总医院;南开大学医学院; |
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| 基金项目： | 国家科技部国际科技合作重大专项课题(2006DFB32210) |
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| 摘 要： | 内质网应激是继死亡受体信号途径和线粒体途径之后新近发现的一条细胞凋亡通路,适度的应激可通过未折叠蛋白反应(UPR)产生细胞保护作用,但当应激过强或长时间不缓解时则会触发CHOP、ASK1/JNK及Caspases等通路诱导细胞凋亡。近年来研究发现内质网应激参与多种心血管疾病的发生发展,通过对相关通路的干预可以产生心肌细胞的保护作用,这有望成为防治心脏疾病的新靶点。
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| 关 键 词： | 内质网应激 凋亡 心血管疾病 细胞保护 |
Research of endoplasmic reticulum stress and cardiovascular diseases |
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| He YY,He KL,Liu CL.Research of endoplasmic reticulum stress and cardiovascular diseases[J].Progress in Physiological Sciences,2011,42(6):419-422. |
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| Authors: | He Yun-Yun He Kun-Lun Liu Chun-Lei |
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| Institution: | HE Yun-Yun1,2,HE Kun-Lun1,LIU Chun-Lei1,2(1General Hospital of Chinese PLA,Beijing 100853,China,2 Medical School of Nankai University,Tianjin 300071,China) |
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| Abstract: | Endoplasmic reticulum stress is a newly discovered pathway of apoptosis,following the death receptor signaling and mitochondrial pathways.Moderate stress triggers the unfolded protein response(UPR) to rsstore the cell function.However,if the stress is severe and/or prolonged,the ER also initiates apoptotic signaling that includes CHOP,ASK1/JNK and caspases pathways.Recent studies have found that endoplasmic reticulum stress plays an important role in the development of various cardiovascular diseases.Also,e... |
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| Keywords: | endoplasmic reticulum stress apoptosis cardiovascular disease cell protection |
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