| 蛋白激酶C与吗啡耐受 |
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| 作者姓名： | Huo YP Hong YG |
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| 作者单位： | 福建师范大学生命科学学院福建省发育与神经生物学重点实验室; |
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| 基金项目： | 国家自然科学基金(30970985)资助课题 |
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| 摘 要： | 蛋白激酶C(protein kinase C,PKC)属于AGC蛋白激酶家族(即PKA/PKG/PKC激酶家族),在吗啡介导的μ-阿片受体脱敏及吗啡耐受中具有重要作用,因此研究PKC的细胞信号传导机制对吗啡耐受的治疗具有重要的临床意义。本文综述了PKC在吗啡耐受中的作用。
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| 关 键 词： | 蛋白激酶C 吗啡耐受 阿片受体 磷酸化 |
Protein kinase C and morphine tolerance |
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| Huo YP,Hong YG.Protein kinase C and morphine tolerance[J].Progress in Physiological Sciences,2011,42(6):423-426. |
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| Authors: | Huo Yu-Ping Hong Yan-Guo |
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| Institution: | HUO Yu-Ping,HONG Yan-Guo(Key Laboratory of Developmental Biology and Neuroscience in Fujian Province,College of Life Sciences,Fujian Normal University,Fuzhou 350108,China) |
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| Abstract: | Protein kinase C (PKC) belongs to the AGC (cAMP-dependent protein kinase/PKG/PKC) protein kinase family which plays an important role in the morphine-induced desensitization of R-opioid receptors. This cellular process is believed to contribute to the development and maintenance of morphine tolerance. Therefore, the study of PKC signaling transduction on morphine tolerance has an important clinical significance. The present review summarizes the possible involvement of PKC in opioid tolerance. |
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| Keywords: | protein kinase C(PKC) morphine tolerance opioid receptor phosphorylation |
| 本文献已被 CNKI PubMed 等数据库收录！ |
