Inheritable forms of medullary thyroid carcinoma |
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Authors: | Bachelot Anne Lombardo Francesca Baudin Eric Bidart Jean-Michel Schlumberger Martin |
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Institution: | Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave-Roussy, Villejuif, France. |
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Abstract: | Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid that produce calcitonin. It accounts for 5-10% of all thyroid cancers. Hereditary MTC represents 20-30% of all MTCs. It can be transmitted with an autosomal dominant pattern, either as a single entity, familial MTC, or it can arise as part of a multiple endocrine neoplasia (MEN) syndrome type 2A or 2B. The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene. |
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