Protective action of a vaccine made from Salmonella minnesota R 595 in the intranasal infection of mice with P. aeruginosa

The comparative study of heated corpuscular vaccines prepared from S. minnesota mutant R 595, chemotype Re, from S. minnesota strain SF 1111 with defective lipopolysaccharide and from P. aeruginosa strain PA 103 has been carried out. The vaccine prepared from the chemotype Re mutant, in contrast to the vaccine prepared from S. minnesota strain SF 1111, has been found to induce the development of active immunity (and the corresponding antiserum, passive immunity) to P. aeruginosa introduced intranasally into mice, as well as to stimulate the elimination of the cells of P. aeruginosa infective strain from the lungs of the mice. The potency of the vaccine prepared from the chemotype Re mutant has been found to be significantly no different from that of the vaccine prepared from P. aeruginosa strain PA 103.