Apport de la biologie moléculaire dans la prise en charge des cancers thyroïdiens : mutation BRAF et miRNA |
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| Authors: | F Savagner |
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| Institution: | 1. Key Laboratory of Inorganic Chemistry in Universities of Shandong, Department of Chemistry and Chemical Engineering, Jining University, Qufu, Shandong 273155, PR China;2. Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Xiamen University, Xiamen, Fujian 361005, PR China;3. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, PR China;1. RSPB Centre for Conservation Science, Royal Society for the Protection of Birds, David Attenborough Building, Pembroke Street, Cambridge CB2 3EZ, United Kingdom;2. RSPB Centre for Conservation Science, Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire SG19 2DL, United Kingdom;3. Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom;4. Royal Zoological Society of Scotland, Edinburgh Zoo, 134 Corstorphine Road, Edinburgh EH12 6TS, United Kingdom |
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| Abstract: | Searching for diagnostic and prognostic molecular markers of thyroid tumors is a major challenge in thyroid oncology, especially in the context of targeted therapies. Its application to fine needle aspiration biopsies depends on the sensitivity for methods used to detect mutations but also on the percentage of cells presenting mutations in the collection. The molecular approach could involve the exhaustive search for mutations in BRAF and RAS, rearrangements in Ret/PTC and PPARγ/PAX8 and expression measurement of selected miRNA. In practice, looking for the BRAF V600E mutation is easy to use on fine needle aspiration biopsies. Its detection could be associated to the measurement of target miRNA (especially miR-146b) to identify papillary carcinoma with poor prognosis. Measurement of several miRNA should have soon a diagnostic interest for follicular tumors according to recent studies exploring atypical tumors on histology. |
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