Development of a novel albumin-binding prodrug that is cleaved by urokinase-type-plasminogen activator (uPA) |
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| Authors: | Chung Da-Eun Kratz Felix |
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| Institution: | Tumor Biology Center, Breisacher Strasse 117, 79106 Freiburg, Germany. |
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| Abstract: | A water-soluble albumin-binding prodrug of doxorubicin EMC-Gly-Gly-Gly-Arg-Arg-DOXO (EMC, 6-maleimidocaproic acid)] was developed that is cleaved specifically by the tumor-associated protease urokinase-type plasminogen activator (uPA). |
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