The Biodegradation of Zein <Emphasis Type="Italic">In Vitro</Emphasis> and <Emphasis Type="Italic">In Vivo</Emphasis> and its Application in Implants |
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Authors: | Teng Lin Chuanhua Lu Ligen Zhu Tao Lu |
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Institution: | (1) Key Laboratory of R&D of Chinese Medicine, Hefei, People’s Republic of China;(2) Department of Pharmaceutics, Anhui University of Medicine, Hefei, People’s Republic of China;(3) Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, 103 Mei Shan Road, Hefei, 230038, People’s Republic of China |
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Abstract: | A unique polymer-based sustained-release implant drug delivery system was prepared by using biocompatible and biodegradable
Zein as the skeleton meterial. After preparing Zein colloids, the Zein-loaded implant rods were formulated by injection molding
followed by evaporating the solvent, and being coated with poly(lactic-co-glycolic) acid (PLGA) solution. Drug release kinetics was examined by using Fluorouracil (5-FU) as model drug. Nearly zero-order
release was achieved for the model drugs for a period of 0–25 days when the implants were incubated in distilled water at
37°C. And then the degradation kinetics of the rods in vivo and in vitro were evaluated, which indicated that Zein could be absorbed by body and has good degradation property. The effects of different
ratios of Zein/5-FU and the rods’ diameter on drug release were studied, respectively. The plasma concentration of 5-FU in
the implants were determined by HPLC after implanting a single dose of the implants in rats. All data were subsequently processed
by using the computer program 3P97, and the values were showed as follows: the area under the plasma concentration–time curve
(AUC) value was 321.88 (μg/ml) × day, and the mean residence time (MRT) value was 23.05 days. The sustained-release implants
of Zein/5-FU were successfully formulated. The uniqueness of the article is that Zein has been used as a skeleton material
in implant delivery system for the first time and zero-order release kinetics has been obtained successfully. |
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