Novel stereoconfiguration in lyso-bis-phosphatidic acid of cultured BHK-cells |
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Authors: | J Brotherus O Renkonen W Fischer J Herrmann |
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Institution: | Laboratory of Lipid Research, Department of Biochemistry, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki 29 Finland;Institute of Physiological Chemistry, University of Erlangen-Nürnberg, Wasserturmstrasse 5, D-8520 Erlangen Germany |
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Abstract: | Lyso-bis-phosphatidic acid purified from cultured hamster kidney fibroblast cells (BHK-cells) was subjected to strong alkaline hydrolysis. The hydrolysate contained phosphorus, free glycerol, total glycerol, α-glycerophosphate, β-glycerophosphate and sn-glycerol-3-phosphate in mole ratios of 1.0:1.0:1.9:0.4:0.6:0.02. The absence of sn-glycerol-3-phosphate indicates that the backbone of this lipid has the uncommon structure of 1-sn-glycerophosphoryl-1′-sn-glycerol. Consequently, the biosynthesis and the degradation of this lipid must differ from the other known mammalian glycerophospholipids. |
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