A liver factor that interconverts multiple forms of tyrosine aminotransferase. |
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Authors: | G J Smith P H Pearce I T Oliver |
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Affiliation: | Department of Biochemistry, University of Western Australia, Nedlands, Western Australia, 6009 |
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Abstract: | Three activity peaks of rat liver soluble tyrosine aminotransferase have been resolved using hydroxyl-apatite chromatography. These peaks interconvert during storage of the soluble enzyme preparation in ice for 20 h. A component of a particulate fraction of liver which will interconvert the forms of tyrosine aminotransferase in vitro with no alteration of total enzyme activity has been detected. This factor is present in a 31, 000 gh pellet of liver and is solubilized by sonication. When the factor is subjected to dialysis or incubation at 25°C for 30 min. its effect on tyrosine aminotransferase is greatly diminished. |
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