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A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids |
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| Authors: | Le Pera Adolfo Leggio Antonella Siciliano Carlo Di Gioia Maria L Napoli Anna Sindona Giovanni Liguori Angelo |
| Institution: | Dipartimento di Scienze Farmaceutiche, Università degli Studi della Calabria, Via P. Bucci, Cubo 15/C, I-87036 Arcavacata di Rende (CS), Italy. |
| Abstract: | A facile and convenient approach to 17-ketosteroids is described. Treatment of steroids containing the C-17-dihydroxy acetone side chain with an excess of sodium methoxide in dry 1,4-dioxane under reflux, affords high yields of the corresponding 17-ketosteroids that are recovered as pure products, without the need of further purification. |
| Keywords: | 17-Ketosteroids Corticosteroids C-17-Dihydroxy acetone side chain cleavage 11β-Hydroxy-pregn-4-ene-3 17-dione 4-Androstene-3 17-dione 4-Androstene-3 11 17-trione |
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