C‐terminal domains of bacterial proteases: structure,function and the biotechnological applications |
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Authors: | J Huang C Wu D Liu X Yang R Wu J Zhang C Ma H He |
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Institution: | State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China |
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Abstract: | C‐terminal domains widely exist in the C‐terminal region of multidomain proteases. As a β‐sandwich domain in multidomain protease, the C‐terminal domain plays an important role in proteolysis including regulation of the secretory process, anchoring and swelling the substrate molecule, presenting as an inhibitor for the preprotease and adapting the protein structural flexibility and stability. In this review, the diversity, structural characteristics and biological function of C‐terminal protease domains are described. Furthermore, the application prospects of C‐terminal domains, including polycystic kidney disease, prepeptidase C‐terminal and collagen‐binding domain, in the area of medicine and biological artificial materials are also discussed. |
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Keywords: | bacteria biotechnology C‐terminal protease domain diversity function structural characteristics |
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