Current status of natural products from plants as anti-herpes simplex virus 1 agents |
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Authors: | Yang-fei Xiang Ying Pei Yi-fei Wang |
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Affiliation: | Biomedicine Research & Development Center, Jinan University, Guangzhou 510630, China |
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Abstract: | Nucleoside analogues have been the mainstay of clinical treatment of herpes simplex virus 1 (HSV-1) infections since their development. However, the emergence of drug resistant strains has underlined the urgency of the discovery of novel anti-HSV-1 drugs. Natural products, which provided many novel drug leads, are known to be an important source of anti-HSV-1 agents. Herein, we present an overview of natural products with anti-HSV-1 activities isolated from a variety of plants reported in recent years. Several different compounds, mainly belonging to the three groups of polysaccharides, polyphenols and terpenes, showed antiviral effects against HSV-1, indicating their potential to be promising anti-HSV-1 agents. |
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Keywords: | Herpes simplex virus 1 (HSV-I) Antiviral Anti-HSV-1 Natural product |
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