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Genetic linkage relationships between the Xg blood group system and two X chromosome DNA polymorphisms in families with Duchenne and Becker muscular dystrophy |
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| Authors: | M Sarfarazi P S Harper H M Kingston J M Murray T O'Brien K E Davies R Williamson P Tippett R Sanger |
| Institution: | 1. Section of Medical Genetics, Department of Medicine, Welsh National School of Medicine, Health Park, CF4 4XN, Cardiff, UK 2. Department of Biochemistry, St. Mary's Hospital Medical School, University of London, W2 1PG, London, UK 3. MRC Blood Group Unit, University College London, Wolfson House, Stephenson Way, NW1 2HE, London, UK |
| Abstract: | The existence of linkage has been investigated between the Xg blood group system, two DNA restriction fragment length polymorphisms (RFLPs) located on the short arm of the X chromosome, Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). No linkage was found between the Xg locus and the more proximal RFLP (L 1.28); close linkage between Xg and the more distal RFLP (lambda RC8) was also excluded. Both RFLPs show linkage with DMD but are not closely linked with each other. Analyses of 11 families with DMD and ten with BMD, informative for the Xg blood group, reinforce the conclusions of others that there is no measurable linkage between the loci for Xg and for the X-linked forms of muscular dystrophy. |
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