A new SUMO ligase in the DNA damage response |
| |
| Authors: | Lee Karen M O'Connell Matthew J |
| |
| Affiliation: | Department of Oncological Sciences, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA. |
| |
| Abstract: | SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
