Production of artemisinin by hairy rot cultures of Artemisia annua L in bioreactor |
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Authors: | C.Z. Liu Y.C. Wang F. Ouyang H.C. Ye G.F. Li |
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Affiliation: | (1) State Key Laboratory of Biochemical Engineering , Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing, 100080, China;(2) Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China |
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Abstract: | Hairy root cultures of Artemisia annua L were cultivated in four different culture systems: a flask, a bubble column, a modified bubble column and a modified inner-loop airlift bioreactor. The artemisinin contents of hairy root cultures in the bubble column and the modified inner-loop airlift bioreactor were higher than that in the modified bubble column. The growth rate and hairy root distribution in the modified inner-loop airlift bioreactor were better than those in other bioreactors, and dry weight and artemisinin production reached to 26.8 g/L and 536 mg/L after 20 days. |
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