Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor |
| |
Authors: | Lin Nan-Horng Wang Le Wang Xilu Wang Gary T Cohen Jerry Gu Wen-Zhen Zhang Haiying Rosenberg Saul H Sham Hing L |
| |
Affiliation: | Cancer Research, R-47B, Global Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA. nanhorng.lin@abbott.com |
| |
Abstract: | Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|