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Screening of ligands for redox-active europium using magnetic resonance imaging |
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| Authors: | Brooke A. Corbin Lina A. Basal Susan A. White Yimin Shen E. Mark Haacke Kenneth W. Fishbein Matthew J. Allen |
| Affiliation: | 1. Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States;2. Department of Radiology, Wayne State University School of Medicine, Detroit, MI 48201, United States;3. Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States;4. National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States |
| Abstract: | We report a screening procedure to predict ligand coordination to EuII and EuIII using magnetic resonance imaging in which bright images indicate complexation and dark images indicate no complexation. Here, paramagnetic GdIII is used as a surrogate for EuIII in the screening procedure to enable detection with magnetic resonance imaging. The screening procedure was tested using a set of eight ligands with known coordination to EuII and EuIII, and results were found to be consistent with expected binding. Validation of the screening procedure with known coordination chemistry enables use with new ligands in the future. |
| Keywords: | Coordination chemistry Europium Magnetic resonance imaging Screening |
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