|
|||||
|
|
Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents |
|
| Authors: | Brian Gabet Ping-Chang Kuo Steven Fuentes Yamini Patel Ahmed Adow Mary Alsakka Paula Avila Teri Beam Jui-Hung Yen Dennis A Brown |
| Institution: | 1. Manchester University College of Pharmacy and Health Sciences, 10627 Diebold Rd, Fort Wayne, IN 46845, United States;2. Department of Microbiology and Immunology, Indiana University School of Medicine, 2101 E. Coliseum Blvd, Fort Wayne, IN 46805, United States |
| Abstract: | A series of simplified berberine analogs was designed, synthesized, and evaluated for anti-inflammatory activity. SAR studies identified N-benzyltetrahydroisoquinoline 7d as a potent berberine analog. 7d suppressed LPS-induced inflammatory cytokine levels in both BV2 cells and primary microglia. Taken together, our results suggest that simplified BB analogs have therapeutic potential as a novel class of anti-neuroinflammatory agents. |
| Keywords: | BB berberine CNS central nervous system EAE experimental autoimmune encephalomyelitis LPS lipopolysaccharide MS multiple sclerosis Berberine Neuroinflammation Multiple sclerosis |
| 本文献已被 ScienceDirect 等数据库收录！ | |