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Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody
Authors:Heng Zhang  Xueyong Zhu  Gabriel Pascual  Jehangir S Wadia  Elissa Keogh  Jeroen J Hoozemans  Berdien Siregar  Hanna Inganäs  Esther JM Stoop  Jaap Goudsmit  Adrian Apetri  Wouter Koudstaal  Ian A Wilson
Institution:1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People''s Republic of China;3. Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121, USA;4. Department of Pathology, Amsterdam Neuroscience, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, the Netherlands;5. Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN Leiden, the Netherlands;6. Department of Neurology, Amsterdam Neuroscience, Academic Medical Center, Meidreefberg 9, 1105 AZ Amsterdam, the Netherlands;7. Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA;8. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:Alzheimer disease  tau  hyperphosphorylation  monoclonal antibody  x-ray crystallography  diagnostics  therapeutics
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