Enhanced neurite outgrowth of rat neural cortical cells on surface-modified films of poly(lactic-<Emphasis Type="Italic">co</Emphasis>-glycolic acid) |
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| Authors: | Dong-Wook?Han Min?Sub Lee Bong?Joo?Park Jeong?Koo?Kim Email author" target="_blank">Jong-Chul?ParkEmail author |
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| Institution: | (1) Department of Medical Engineering, Yonsei University College of Medicine, 134 Shinchon-dong,Seodaemun-gu, 120-752 Seoul, Korea;(2) Department of Biomedical EngineeringCollege of Biomedical Science and Engineering, Inje University, Kimhae, 621-749, Korea;(3) Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, 120-752, Korea |
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| Abstract: | Neural cortical cells, isolated from prenatal rat cerebra, were grown on surface-modified poly(lactic-co-glycolic acid, 65:35) (PLGA) films coated with poly-D-lysine (PDL) with either laminin (LN), fibronectin (FN) or collagen (CN). Immunocytochemistry showed that the isolated cells were highly immunopositive for both neurofilament and MAP-2 with well-organized neurites and somatodendritic localization. The presence of PDL with LN or FN on the PLGA films was essential for increased neural cell growth. Also, PLGA films coated with either PDL/LN or PDL/FN mixtures had higher neurite outgrowth and regular differentiation.Revisions requested 30 September 2004; Revisions received 10 November 2004 |
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| Keywords: | extracellular matrix neurite outgrowth poly(lactic-co-glycolic acid) rat neural cortical cell |
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