Cytotoxic derivatives of (22R,23R)-dihydroxystigmastane |
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| Authors: | F V Drozdov A P Mekhtiev G E Morozevich V P Timofeev A Yu Misharin |
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| Institution: | (1) Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832, Russia;(2) Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984, Russia |
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| Abstract: | (22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23-dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3β,5α,6β,22,23-pentahydroxystigmastane, (22R,23R)-5α,6α-oxido-3β,22,23-trihydroxystigmastane, (22R,23R)-5β,6β-oxido-3β,22,23-trihydroxystigmastane, and (22R,23R)-3β,6β,22,23-tetrahydroxystigmast-4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line. |
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| Keywords: | cytotoxicity Hep G2 cells MCF-7 cells oxysterols |
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