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Pulmonary cryptococcosis in late pregnancy and review of published literature |
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| Authors: | Nakamura Shigeki Izumikawa Koichi Seki Masafumi Kakeya Hiroshi Yamamoto Yoshihiro Yanagihara Katsunori Miyazaki Yoshitsugu Kohno Shigeru |
| Institution: | (1) Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan;(2) Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan;(3) Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan;(4) Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan; |
| Abstract: | Naturally occurring maternal immunosuppression increases the risk of infection by a variety of pathogens during pregnancy and the postpartum period. Pulmonary cryptococcosis during pregnancy is relatively rare. Here, we report on two cases of pulmonary cryptococcosis during pregnancy and puerperium. Both cases were successfully treated using oral fluconazole after parturition to avoid fetal toxicity. For the two patients, the placentas were checked and found to be pathologically normal, and the cryptococcal serum antigen in both infants was negative. Pulmonary cryptococcosis should be considered during differential diagnosis as a possible cause of abnormal chest shadow in pregnant patients. |
| Keywords: | Cryptococcus neoformans Fluconazole Pregnancy Pulmonary cryptococcosis Immunosuppression |
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