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Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare |
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| Authors: | Arjun H Banskota Yasuhiro Tezuka Le Kim Phung Kim Qui Tran Ikuo Saiki Yoshihisa Miwa Tooru Taga Shigetoshi Kadota |
| Institution: | a Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 30-0194, Japan b Hochiminh City Traditional Medicine School, Hochiminh, Vietnam c National University Hochiminh City, Hochiminh, Vietnam d Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyoku, Kyoto 606-8501, Japan |
| Abstract: | Seven novel cycloartane-type triterpenes were isolated from Combretum quadrangulare, and their structures were elucidated on the basis of spectral analysis. All these compounds were tested for their cytotoxicity against murine colon 26-L5 carcinoma cells. Methyl quadrangularate B (2) and methyl quadrangularate D (4) exhibited potent cytotoxicity having ED50 values 9.54 and 5.42 μM, respectively. |
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