| Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches? |
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| 引用本文： | Grüner AC,Snounou G,Brahimi K,Letourneur F,Rénia L,Druilhe P. Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches?[J]. Trends in parasitology, 2003, 19(2): 74-78. DOI: 10.1016/S1471-4922(02)00067-3 |
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| 作者姓名： | Grüner AC Snounou G Brahimi K Letourneur F Rénia L Druilhe P |
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| 摘 要： |
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Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches? |
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| Grüner Anne Charlotte,Snounou Georges,Brahimi Karima,Letourneur Franck,Rénia Laurent,Druilhe Pierre. Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches?[J]. Trends in parasitology, 2003, 19(2): 74-78. DOI: 10.1016/S1471-4922(02)00067-3 |
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| Authors: | Grüner Anne Charlotte Snounou Georges Brahimi Karima Letourneur Franck Rénia Laurent Druilhe Pierre |
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| Affiliation: | Unité de Parasitologie Biomédicale, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France. |
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| Abstract: | A growing number of Plasmodium genomes have joined the sequencing treadmill, and the genome of Plasmodium falciparum has recently been published. Most malaria vaccinologists will soon be confronted by a bewildering array of new potential antigens from the recently completed genome of this parasite. However, for those aiming to target the pre-erythrocytic stages of the hepatic parasite, the wait might be long. In the absence of readily available materials and specific reagents, the selection of pre-erythrocytic antigens from raw sequence data is likely to prove difficult. Here, current knowledge of pre-erythrocytic antigens is updated in the light of recent results, and the post-genomic prospects of completing the antigenic repertoire of these immunologically important and intriguing stages is discussed. |
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