Effects of smoking and tumor process on the contents of key proteins of apoptosis and activity of antioxidant enzymes in blood |
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Authors: | E M Mil’ S M Gurevich A I Kozachenko L G Nagler A A Albantova L D Fatkullina E B Burlakova |
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Institution: | 1.Emanuel Institute of Biochemical Physics,Russian Academy of Sciences,Moscow,Russia |
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Abstract: | The effects of smoking on the contents of the apoptosis markers Bcl-2 and p53 proteins in blood plasma; the activity of the
antioxidant (AO) enzymes Cu,Zn superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), glutathione
S-transferase (GST), and catalase; and the content of malondialdehyde (MDA) in erythrocytes from healthy donors and cancer
patients were studied. Two groups of donors were revealed among healthy smokers: one with high SOD and GP activities and high
Bcl-2 protein levels and the other with lower Bcl-2 levels compared with those found in nonsmokers. In the group of cancer
patients (both smokers and nonsmokers), significantly increased p53 protein levels and increased activity of GST were found.
A negative correlation between MDA and GST in the group of smoking healthy donors and a positive correlation between MDA and
p53 in cancer patients were found. The results suggest a relationship between the components of enzymatic defence and lipid
peroxidation and the content of apoptosis regulator proteins in healthy smokers and cancer patients. |
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Keywords: | |
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