Osteosclerotic myeloma with polyneuropathy and hypocalcemia |
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Authors: | C Ludescher K Grünewald F Fend O Dietze J Thaler K W Schmid |
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Affiliation: | Department of Pathology, University of Innsbruck, Austria. |
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Abstract: | A case is presented of a 46-year-old man with multifocal osteosclerotic bone lesions, peripheral polyneuropathy and hypocalcemia. Histologic examination of a bone marrow biopsy disclosed a multiple myeloma. Immunoelectrophoresis revealed a small M-component identified as IgG-lambda. Osteosclerotic myeloma lacking any osteolytic lesions seems to be very rare and shows several different features as compared with classical myeloma. A review of the current literature suggests that multiple myeloma is not a uniform disease but rather a group of clinical syndromes characterized by the special properties of their proliferating plasma cell clones. |
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