Regulation of inflammatory responses by oncostatin M |
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Authors: | Wallace P M MacMaster J F Rouleau K A Brown T J Loy J K Donaldson K L Wahl A F |
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Affiliation: | Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA. philipvwallace@msn.com |
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Abstract: | Oncostatin M (OM) is a pleiotropic cytokine produced late in the activation cycle of T cells and macrophages. In vitro it shares properties with related proteins of the IL-6 family of cytokines; however, its in vivo properties and physiological function are as yet ill defined. We show that administration of OM inhibited bacterial LPS-induced production of TNF-alpha and lethality in a dose-dependent manner. Consistent with these findings, OM potently suppressed inflammation and tissue destruction in murine models of rheumatoid arthritis and multiple sclerosis. T cell function and Ab production were not impaired by OM treatment. Taken together these data indicate the activities of this cytokine in vivo are antiinflammatory without concordant immunosuppression. |
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