Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines |
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| Authors: | de Fatima Angelo Kohn Luciana Konecny Antônio Márcia Aparecida de Carvalho João Ernesto Pilli Ronaldo Aloise |
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| Institution: | Instituto de Quimica, Unicamp, CP 6154, 13084-971, Campinas, S?o Paulo, Brazil. |
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| Abstract: | Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described. |
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