Bombesin-like peptides and receptors in human tumor cell lines |
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Authors: | T W Moody V Bertness D N Carney |
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Affiliation: | 1. Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037 USA;2. NCI-Navy Medicine Oncology Branch, National Cancer Institute, Bethesda, MD 20814 USA;3. National Navy Medical Center, Bethesda, MD 20814 USA |
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Abstract: | Human cancer cell lines were assayed for bombesin-like peptides and receptors. Acid extracts derived from small cell lung cancer, but not other types of cancer had high levels of immunoreactive bombesin. Regardless of patient treatment, site of tumor origin (bone marrow, lymph node, or pleural effusion) or culture conditions, small cell lung cancer cell lines had high levels of bombesin-like peptides. Thus, bombesin levels in small cell lung, but not other types of human cancer, are routinely elevated. Also, small cell lung cancer lines in contrast to other cell lines have a high density of binding sites for a radiolabeled bombesin analogue. The presence of high concentrations of bombesin-like peptides and receptors suggests that bombesin may function as an important regulatory agent in human small cell lung cancer. |
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Keywords: | Neuroendocrine peptides Bombesin Bombesin receptors Cancer Small cell lung cancer |
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