The effect of lithium on chronic haloperidol enhanced apomorphine aggression in rats |
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| Authors: | L H Allikmets M Stanley S Gershon |
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| Institution: | 1. Department of Pharmacology Tartu University Tartu, Estonia, U.S.S.R. 202400;2. Neuropsychopharmacology Research Unit Department of Psychiatry New York University Medical Center 550 First Avenue New York, N.Y. 10016, USA |
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| Abstract: | The effect of chronic haloperidol or haloperidol plus lithium on apomorphine-induced aggressive and stereotyped behaviors was assessed. Rats withdrawn from chronic haloperidol treatment showed increased aggressiveness and had an increased duration of stereotyped behavior. Rats treated chronically with haloperidol in combination with lithium did not display a supersensitive response. These findings are discussed in relation to the results of other investigators. |
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| Keywords: | Correspondence |
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