糖尿病植物神经病变病人心率变异的非线性定量分析

目的：研究糖尿病人植物神经病变与心率变异的关系。对象：正常对照组和根据临床有无糖尿病神经病变（ＤＡＮ）分组的糖尿病病人，方法：应用２４小时动态心电图对正常和糖尿病人进行心率变异的线性，非线性散点图和非线性定量参数分析，结果：单纯糖尿病组ＳＤＮＮ，ＳＤＡＮＮ和ＰＮＮ５０低于正常组（Ｐ〈０．０５）；糖尿病＋ＤＡＮ组各项线性时域分析指标均低于正常和单纯糖尿病组（Ｐ〈０．０１－０．００１），散点图分析结果

Quantitative analysis of nonlinear heart rate variability in diabetic autonomic neuropathy

The time domain: nonlinear Poincare plot and nonlinear quantitative analyysis of heart rate variability were studied from 24 - hours ambulatory electrocardiogram in 22 diabetic patients without diabetic autonomic neuropathy (DAN) (Group DAN - ), 18 diabetic patients with DAN (Group DAN )and 30 healthy controls (Group C).The results showed that SDDNN.SDANN and PNN50 were markly decreased in Group DAN -compared with Group C(P<0. 05). In Group DAN the indidcators of all heart rate variability in time Domain were decreased obviously compared with Group C and Group DAN-(P<0.01-0. 001). nonlinear studying,Group C showed a comet -shaped Poincare Plot patterns. Most subjects in Group DAN -exhibit a torpedo-shaped Poincare plot patterns and thd majority of Group DAN had a short stick - shaped Poincare plot patterns. The results of nonlinear quantitative analysis presented that vector angle index ( VAI) : short axis and area of plot in Group DAN -were lower than that in Group C. The indices of vector length index(VLI), VAI,long axis,short axis and area of plot in Group DAN were much lower than that in Group C and Group DAN- (P<0. 01~P<0. 001).The results indicated that the heart rate variability has a good relationship with diabetic autonomic neuropathy in clinical and have a hope to become the effective objective diagnosis standard. Also the analysis of nonlinear heart rate variability can help to predict the risk stratification in diabetes.