| Semaphorins家族在肺发育与肺疾病中作用的研究进展 |
| |
| 引用本文： | 罗颖婉,楼浙伟,吴泓蔚,吴雅君,王勤泉,黄智慧. Semaphorins家族在肺发育与肺疾病中作用的研究进展[J]. 细胞生物学杂志, 2012, 0(11): 1156-1165 |
| |
| 作者姓名： | 罗颖婉 楼浙伟 吴泓蔚 吴雅君 王勤泉 黄智慧 |
| |
| 作者单位： | [1]温州医学院第一临床学院,温州325035 [2]温州医学院基础医学院,温州325035 |
| |
| 基金项目： | 温州医学院本科生创新项目（No.wyx201101009）; 浙江省教育厅基金（No.Y200906728）; 浙江省自然科学基金（No.Y2110364,No.Y2110242）资助项目 |
| |
| 摘 要： | Semaphorins家族是一类经典的神经元轴突导向排斥性因子。最近大量研究表明,该家族除了在神经系统内发挥作用外,在肺发育与肺疾病中也起着重要作用。Semaphorins家族可通过调节肺泡上皮细胞、肺内皮细胞的增殖、黏附、迁移和凋亡,促进或抑制肺与血管的正常发育和病理过程。该文将对现阶段Semaphorins家族对肺发育过程中肺分支形成、血管形成和肺相关疾病作用的最新研究进展进行综述。
|
| 关 键 词： | Semaphorins 肺形成 血管生成 肺部疾病 |
Semaphorins in Lung Development and Pulmonary Diseases |
| |
| Luo Yingwan,Lou Zhewei,Wu Hongwei,Wu Yajun,Wang Qinquan,Huang Zhihui. Semaphorins in Lung Development and Pulmonary Diseases[J]. Chinese Journal of Cell Biology, 2012, 0(11): 1156-1165 |
| |
| Authors: | Luo Yingwan Lou Zhewei Wu Hongwei Wu Yajun Wang Qinquan Huang Zhihui |
| |
| Affiliation: | 1.Department of Clinic Medicine, Wenzhou Medical College, Wenzhou 325035, China; 2.Department of Basic Medicine, Wenzhou Medical College, Wenzhou 325035, China) |
| |
| Abstract: | Semaphorins are a large family of secreted and transmembrane signaling proteins that repel axons in the developing nervous system. Recent studies have shown that Semaphorins are involved in the develop-ment of lung and pulmonary diseases through regulating cell proliferation, adhesion, motility and apoptosis. This review focuses on the emerging roles of the Semaphorins in lung branching morphogenesis, angiogenesis and pul-monary diseases. |
| |
| Keywords: | Semaphorins lung morphogenesis angiogenesis pulmonary diseases |
| 本文献已被 维普 等数据库收录！ |
|
