Phylogeny and molecular epidemiology of Sporothrix schenckii in Japan |
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Authors: | Yukimasa Takeda Masako Kawasaki Hiroshi Ishizaki |
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Affiliation: | (1) Department of Dermatology, Kanazawa Medical University, Uchinada, 920-02 Ishikawa, Japan |
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Abstract: | Mitochondrial DNA(mtDNA) diversity was investigated in 257 clinical isolants of Sporothrix schenckii obtained from 4 districts in Japan. S. schenckii was classified into 10 types based on Hae III restriction profiles. Phylogeny of types constructed by the method of Fitch and Margoliash [1] on the estimated sequence divergence within mtDNA using the methods of Nei and Li [2], showed that S. schenckii are grouped into 2 clusters, one group consisting of types 1, 2 and 3, and the other group consisting of the other seven types. In addition, types 1, 2, and 5 were correlated with their geographic origin, whereas type 4 was present throughout Japan. |
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Keywords: | DNA epidemiology mitochondria phylogeny restriction profiles Sporothrix schenckii |
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