模拟青霉素发酵过程中菌体生长动态的细胞自动机模型

在青霉素发酵生产机理及其动力学微分方程模型的基础上，建立了模拟青霉素分批发酵过程中菌体生长动态的细胞自动机模型(CABGM)。CABGM采用三维细胞自动机作为菌体生长空间，采用Moore型邻域作为细胞邻域，其演化规则根据青霉素分批发酵过程中菌体生长机理和动力学微分方程模型设计。CABGM中的每一个细胞既可代表单个的青霉素产生菌，又可代表特定数量的青霉素产生菌，它具有不同的状态。对CABGM进行了统计特性的理论分析和仿真实验，理论分析和仿真实验结果均证明了CABGM能一致地复现动力学微分方程模型所描述的青霉素分批发酵菌体生长过程。最后，对所建模型在实际生产过程中的应用问题进行了分析，指出了需要进一步研究的问题。

A CELLULAR AUTOMATA MODEL FOR SIMULATING PENICILLIN FERMENTATION PROCESS BIOMASS GROWTH

A simulating biomass growth cellular automata model (CABGM for short) in penicillin batch fermentation process was constructed on the base of mechanism and dynamic differential equation model of penicillin batch fermentation process. CABGM adopts three-dimensional cellular automata as its growth space, adopts Morre type neighbourhood as its cell neighbourhood. The transition rules of CABGM were made based on mechanism and dynamic differential equation model of penicillin batch fermentation biomass growth process. Every cell of CABGM represents a single or specific number of penicillin production bacteria, and has various states. The results of statistic property theory analysis and simulation experiment show that CABGM replicated penicillin batch fermentation biomass growth process described by dynamic differential equation model accordantly. Finally, the application problem of CABGM in practical production processes is analyzed, and the future study problems are pointed out.