Plasma membrane redox and regulation of cell growth |
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Authors: | F. L. Crane I. L. Sun E. E. Sun R. A. Crowe |
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Affiliation: | (1) Department of Biological Sciences, Purdue University, 47907-1392 West Lafayette, IN, USA |
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Abstract: | Summary Gene expression can be activated by external oxidants which are reduced at the cell surface by plasma membrane electron transport. The signals generated in response to the plasma membrane electron transport include activation of proton release, internal calcium changes, and change in reductant/oxidant ratio in the cytosol. H2O2 generated in response to ligands which bind to plasma membrane receptors can also activate protein tyrosine kinases and gene expression. Inhibition of oxygen radical generation at the cell surface in response to the mitogen, phorbol myristate acetate by retinoic acid is consistent with a role for the plasma membrane electron transport as the source for H2O2 in Balb 3T3 cells. Agents which affect the binding of coenzyme Q to redox sites in the plasma membrane electron transport may increase formation of semiquinone radicals in the membrane which can be a source of oxygen radicals and H2O2. The generation of H2O2 by transformed cells indicates that oncogene product expression in the plasma membrane may also increase quinone-based oxygen radical generation. |
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Keywords: | Growth control Oxidative gene control Plasma membrane electron transport Cellular peroxide Superoxide |
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