Probable mechanism of sexual dimorphism in insulin control of Drosophila heat stress resistance |
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| Authors: | Nataly E Gruntenko Evgenia K Karpova Elena V Burdina Natalya V Adonyeva Olga V Andreenkova Alexander A Alekseev Inga Y Rauschenbach |
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| Institution: | 1. Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia;2. Institute of Chemical Kinetics and Combustion, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia |
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| Abstract: | Adult males of Drosophila species (Drosophila melanogaster L. and Drosophila virilis) show a lower tolerance to heat stress compared with females. The present study investigates the effects of RNA interference (RNAi) knockdown of the insulin‐like receptor in the corpus allatum of D. melanogaster males on dopamine metabolism and content, heat stress resistance and juvenile hormone metabolism. In male flies, the knockdown of insulin‐like receptor in the corpus allatum is shown to change metabolism of juvenile hormone but not dopamine. It is also shown that knockdown of the insulin‐like receptor in the corpus allatum results in a decrease of heat stress resistance in females but not males, and that juvenile hormone rescues this decrease. The results suggest that at least one of the ways in which insulin‐like growth factors affect heat stress resistance is by successive mediation through juvenile hormone and dopamine, which could lead to sexual dimorphism in the trait. |
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| Keywords: | Dopamine Drosophila melanogaster heat stress resistance insulin signaling juvenile hormone sexual dimorphism |
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