Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients |
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Authors: | Chyi-Huey Bai Jiunn-Rong Chen Hou-Chang Chiu Chia-Chi Chou Lee-Young Chau Wen-Harn Pan |
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Affiliation: | (1) Central Laboratory, Shin Kong WHS Memorial Hospital, Taipei, Taiwan;(2) School of Public Health, Taipei Medical University, Taipei, Taiwan;(3) Changhua Christian Hospital Yunlin Branch, Yun-Lin County, Taiwan;(4) Department of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan;(5) Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan;(6) Institutes of Biomedical Sciences, Academia Sinica, Taipei, Taiwan |
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Abstract: | Background The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT)n repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. |
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