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Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients
Authors:Chyi-Huey Bai  Jiunn-Rong Chen  Hou-Chang Chiu  Chia-Chi Chou  Lee-Young Chau  Wen-Harn Pan
Institution:(1) Central Laboratory, Shin Kong WHS Memorial Hospital, Taipei, Taiwan;(2) School of Public Health, Taipei Medical University, Taipei, Taiwan;(3) Changhua Christian Hospital Yunlin Branch, Yun-Lin County, Taiwan;(4) Department of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan;(5) Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan;(6) Institutes of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Abstract:

Background  

The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT)n repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL.
Keywords:
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